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1029d · Science
https://www.nature.com/articles/d41586-022-03836-9 Whats your favourite parasite? Mines Toxoplasma gondii. I suspected I am probably among the infected though, so maybe thats the parasite talking..
replied 1029d
Conventional wisdom states it makes its host ‘bolder’ to increase likelihood of them ending up in a feline stomach. I suspect there is more to the story though..
replied 1029d
Surely there are better strategies for the parasite than increased host ‘boldness’ e.g semi-paralysis, visual impairment etc. Why boldness?.. well, pure speculation, but..
replied 1029d
A strategy that is 100% beneficial for parasite and 100% detrimental for host would 100% incentivise host adaptation to 100% immunity. Bad news for parasite..
replied 1028d
How about... a parasite cannot just intelligently pick parasitic features from a menu. Probably the "features" are hacks that happen to work, ish. Then improved upon a bit over time.
replied 1028d
Yep, but after all those random hacks we seem to arrive at an equilibrium that is a compromise to both parasite and host, but viable for both.
replied 1028d
A parasite might fair better in one genotype than another. So it kinda needs that genotype/lineage to survive, even if it needs the specific host to die..
replied 1028d
My point is even without sentience, the relationship is more akin to farmer and cattle, than hunter and prey.
replied 1028d
OK, but my reply was mostly to your "Why boldness?". The immune system of a mouse, while certainly not impenetrable, can be difficult to attack, and boldness might just have been the
replied 1028d
Fair. I can’t think of an experiment that would determine if ‘boldness’ is an easy hack vs symbiotic sweet spot. It’s all speculation on my part.
replied 1028d
part that happened to be most easy to attack. While I don't necessarily accept your suggestion that your other "strategies" would be better, they may have been harder to implement.
replied 1028d
Also I'd like to point out that I spent a lot of time in my youth studying a mouse called Mickey, and it was often seen with a magnifying glass, negating visual impairment.
replied 1028d
I recall another mouse named Jerry who’s bold traits seemed to consistently keep him out of a feline stomach. Go figure.
replied 1028d
A very reasonable hypothesis! But I'd like to advice caution before a proper Scientific analysis has been performed to see whether said boldness is the actual cause and so on.
replied 1028d
A double blind experiment might shed some light on this: Both the cat and the mouse is given a blindfold. To make it simpler a man named Occam might lend the cat a razor as weapon
replied 1028d
Now I think about it, I also studied this mouse called Jerry, and I do not remember many other dangers it was subject to, beyond a fat woman standing on a chair screaming.
replied 1028d
Maybe an odd sleeping dog. Either way, if this is the common situations for mice, boldness should favor the fortune, or was that the cat.
replied 1029d
But.. facilitating a live-fast-die-young behaviour pattern in the host is something of a compromise. Sure, more hosts die, but maybe these mice father more kids before they do…
replied 1029d
…passing on the traits the parasite needs to warp and exploit. After all, parasite and host evolve together. The battle is never lost or won.