Interesting - do you think it would work with USB microscopes/etc. ?
In particular the focus settings are somewhat crucial for such things.
Cheese was always my scope choice...
I would say Guvcview works with anything supported by Video4Linux. If your equipment works with Cheese, then it should work with Guvcview as well.
Regarding focus settings, it depends whether such functionality is available for your device. I have a Logitech webcam with autofocus and I can adjust the focus manually on Guvcview.